Where is Colchicum found?

It is a member of the botanical family Colchicaceae, and is native to West Asia, Europe, parts of the Mediterranean coast, down the East African coast to South Africa and the Western Cape. In this genus, the ovary of the flower is underground.

What is the local name for Colchicum?

meadow saffron

Colchicum autumnale, commonly called autumn crocus or meadow saffron, is a cormous perennial that typically blooms in early fall.

Where is colchicine obtained from?

Colchicine is one of the oldest remedies still in use today. It is derived from the bulb-like corms of the Colchicum autumnale plant, also known as autumn crocus.

What is Colchicum used for?

Colchicine is used to prevent gout attacks (sudden, severe pain in one or more joints caused by abnormally high levels of a substance called uric acid in the blood) in adults. Colchicine (Colcrys) is also used to relieve the pain of gout attacks when they occur.

What is the biological source of Colchicum?

Colchicine. Colchicine is derived from the autumn crocus (Colchicum autumnale).

What is colchium in English?

Colchicum (/ˈkɒltʃɪkəm/ or /ˈkɒlkɪkəm/) is a genus of perennial flowering plants containing around 160 species which grow from bulb-like corms.

Are Colchicum poisonous?

Introduction. Colchicum autumnale (autumn crocus) is a plant that contains highly toxic alkaloid colchicine.

What plants contain colchicine?

Colchicine. Colchicine is an alkaloid derived from two plants of the lily family, Colchicum autumnale and Gloriosa superba, that was first recommended for the treatment of gout in the sixth century A.D.7 It remains widely in use today for the treatment of acute gout.

What herbs contain colchicine?

Colchicum autumnale (autumn crocus) along with other sources of colchicine, including Gloriosa superba (flame lily), are described, both for their historical significance and relevance to the drug colchicine and also for their use as whole herbs.

Is colchicine toxic to humans?

Ingestion of colchicine typically leads to profuse vomiting and diarrhea, which can be bloody, followed by hypovolemic shock and multisystem organ failure within 24-72 hours. Coma, convulsions, and sudden death might also occur.

Can colchicine be harmful?

Colchicine can cause significant toxicity and death. Colchicine has a narrow therapeutic index, which means that the range between therapeutic and toxic doses is small, and in some cases they overlap.

Which plant is used to extract Colchicum?

Colchicine is an alkaloid present in the seeds of Colchicum autumnale L. and Colchicum luteum L., as well as in tubers of Gloriosa superba L. (family Liliaceae) [4]. Gloriosa grows throughout the tropical region in India and is a well-known source of colchicine.

Is Colchicum a plant drug?

Autumn crocus (Colchicum autumnale L.) is a medicinal plant as it contains high concentrations of colchicine.

Does Colchicum help gout?

Colchicine is used to prevent or treat attacks of gout (also called gouty arthritis). This condition is caused by too much uric acid in the blood. An attack of gout occurs when uric acid causes inflammation (pain, redness, swelling, and heat) in a joint.

What is the most poisonous plants on Earth?

7 of the World's Deadliest Plants

• Water Hemlock (Cicuta maculata) …
• Deadly Nightshade (Atropa belladonna) …
• White Snakeroot (Ageratina altissima) …
• Castor Bean (Ricinus communis) …
• Rosary Pea (Abrus precatorius) …
• Oleander (Nerium oleander) …
• Tobacco (Nicotiana tabacum)

What is the deadliest poisonous plant?

Oleander Nerium

Every portion of this plant is packed of toxins, making it the most dangerous plant on the planet. Oleandrin and neriine are two of the most potent. The poison of an oleander is so potent that it can even poison someone who eats honey created by bees that have ingested oleander nectar.

What is similar to colchicine?

• Naproxen.
• Indocin.
• Ibuprofen.
• Methylprednisolone.
• Advil.
• MethylPREDNISolone Dose Pack.

Why colchicine is used in Covid?

• When colchicine is administered early in the course of COVID-19, these mechanisms could potentially mitigate or prevent inflammation-associated manifestations of the disease.

What is the cause of death from colchicine?

Death results from rapidly progressive multi-organ failure and sepsis. Delayed presentation, pre-existing renal or liver impairment are associated with poor prognosis. 3) Recovery typically occurs within a few weeks of ingestion, and is generally a complete recovery barring complications of the acute illness.

Is colchicine a natural drug?

• Colchicine 32 is a naturally occurring alkaloid from the plant meadow saffron (Colchium autumnnale L.). It was used as a poison in Roman times but was not isolated in pure form until 1820.

Who should not take colchicine?

Muscle damage warning: Colchicine can damage your muscles if you take it for 6 months or longer. Your risk is higher if you're a senior. Taking other drugs that cause muscle damage, such as cholesterol medications, may increase this risk.

Can colchicine cause hair loss?

Hair loss resulting from colchicine poisoning presents as anagen effluvium, as it occurs with an exposure to toxic chemicals. Pharmacotherapy or specific treatment is not usually required, since the follicle resumes its normal activity after withdrawal of the antimitotic factors.

Is colchium toxic?

Autumn crocus (Colchicum autumnale L.) is a medicinal plant as it contains high concentrations of colchicine. In this study, we reported that the ground powder of autumn crocus bulb is highly toxic to invasive Solenopsis invicta Buren, commonly referred to as red imported fire ants (RIFAs).

Can colchicine damage kidneys?

Kidney injury

Although not common, there are some studies showing direct toxicity of the kidneys due to the use of colchicine. They report kidney damage as well as the potential for kidney failure from the direct toxic effect of colchicine on the kidney tubules.

Is it OK to take colchicine every day?

Take this medicine regularly as directed by your doctor, even if you feel well. If you are taking colchicine to prevent gout attacks, and you are also taking another medicine to reduce the amount of uric acid in your body, you probably will be able to stop taking colchicine after a while.

What flower causes heart attacks?

Foxglove (Digitalis purpurea) is a common garden plant that contains digitalis and other cardiac glycosides. These chemicals affect the heart. Foxglove is poisonous, although recorded poisonings from this plant are very rare.